By Linda A. Felton, James W. McGinity
Aqueous-based movie coating has develop into regimen within the pharmaceutical undefined. This method removes using natural solvents and hence avoids monetary, environmental, and toxicological matters concerning residual solvents and solvent restoration. Aqueous-based coating, even though, is advanced and plenty of variables may possibly influence the ultimate product and its functionality. This fourth version of Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms goals to supply perception into the standards and parameters that are meant to be thought of and regulated for the winning improvement and commercialization of a covered product.
The fourth version has been revised and increased to mirror the latest clinical developments from the literature. The contributing authors clarify intimately, utilizing illustrated examples, applicable steps to unravel and preferably steer clear of formula, processing, and balance difficulties and to accomplish an optimized dosage shape. alternate names and chemical names of commercially advertised coatings are used during the textual content to assist familiarize the reader with many of the fabrics on hand for pharmaceutical functions. This publication may be a beneficial source for an individual within the pharmaceutical operating within the sector of aqueous-based movie coating.
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25). 9%, 12%, 16%, cured and uncured 0 2 4 Hours 6 8 10 Effect of PGML on Theophylline release. Curing was 2 hours at 60°C/75% RH. 9% PGML). 24 Uncured 10 60°C/2 hours 0 2 4 6 Time (hours) 10 8 Release from Diltiazem pellets with 10% coated of Aquacoat® ECD 30 with 12% PGML. 25 PGML. 26 Effect of PGMC use level on Theophylline dissolution profile. The curing condition was 60°C/75% RH/2 hours. 27 Dissolution profiles with Diltiazem HCl pellets coated with ECD-30 coating formulated with 12% PGML (♦), SMO (*) or SML (▴).
This is consistent with the strength and cohesiveness of films obtained immediately when deposited from good organic solvents due to complete solvation and maximum extension of polymer chains. Interdiffusion may take longer in latex films, especially if coalescence is not complete. Bradford and Vanderhoff  studied the changes in structure occurring in an uncured, continuous, transparent film as a function of film age. Using transmission electron microscopy within hours of casting, vestiges of the original latex particles could be seen, which disappeared over a 14-day period, accompanied by the exudation of material from within the film, assumed to be a hydrophilic stabilizer.
Carlin, J. T. 14. Curing can be carried out by oven heating or in situ heating in a fluid-bed coater using increased fluidization to avoid pellet agglomeration. Coating is normally carried out below the Tg of the film to minimize tackiness, especially under the low bulk fluidization conditions in the slowly percolating pellet bed outside the Wurster column. , Opadry®) watersoluble polymer top coating can be applied to enable low fluidization curing above the Tg. 14 retested after storage at 40°C/75% RH for periods of up to 8 months.