Advances in Virus Research by Karl Maramorosch; Aaron J. Shatkin; Frederick A. Murphy

By Karl Maramorosch; Aaron J. Shatkin; Frederick A. Murphy (Eds.)

Released due to the fact that 1953, Advances in Virus learn covers a various variety of in-depth experiences offering a worthwhile evaluate of the present box of virology. The effect issue for 2007 is 3.120 putting it ninth within the hugely aggressive classification of virology.* Contributions from major gurus * Informs and updates on the entire most modern advancements within the box

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W. ), pp. 49–64. Informa Healthcare. Kim, C. , Williams, M. , Chen, M. , Mendel, D. , Tai, C. , and Stevens, R. C. (1997). Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J. Am. Chem. Soc. 119:681–690. Kissman, H. , Child, R. , and Weiss, M. J. (1957). Synthesis and biological properties of certain 5, 6-dichlorobenzimidazole ribosides.

The latter was finally formulated as TDF and approved by the US Food and Drug Administration (FDA) for clinical use, for the treatment of HIV infections, in October 2001, within 8 years after it had been first described. Then followed the FDA approval for the combination of TDF with emtricitabine (TruvadaÒ ) in August 2004 and for the combination of TDF with emtricitabine and efavirenz (AtriplaÒ ) in July 2006. The route from adefovir to AtriplaÒ, via tenofovir, VireadÒ, and TruvadaÒ , has been recently described (De Clercq, 2006b), as has been the importance of the phosphonate bridge in the antiviral activity of the acyclic nucleoside phosphonates (De Clercq, 2007; De Clercq and Holy´, 2005).

From adefovir to AtriplaTM via tenofovir, VireadTM and TruvadaTM. Future Virol. 1:709–715. De Clercq, E. (2007). Acyclic nucleoside phosphonates: Past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: The phosphonate bridge. Biochem. Pharmacol. 73:911–922. De Clercq, E. (2008a). Emerging antiviral drugs. Expert Opin. Emerg. Drugs 13:393–416. De Clercq, E. (2008b). The discovery of antiviral agents: Ten different compounds, ten different stories.

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