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Advances in Vascular Medicine by Ioannis Papaioannou, James S. Owen (auth.), David Abraham,

By Ioannis Papaioannou, James S. Owen (auth.), David Abraham, Handler Clive, Michael Dashwood, Gerry Coghlan (eds.)

Understanding the various complicated mobile and molecular mechanisms underlying human vascular illnesses is key in enhancing the administration of sufferers with this clinically vital and wide-ranging team of illnesses. this can be rather vital whilst contemplating the level of this factor around the world.

Written via a crew of world-renowned gurus, Advances in Vascular Medicine highlights a few of the relationships among easy technological know-how and scientific medication, and stories either study and scientific perform tools and results in vascular biology and pathobiology. it's an authoritative reference for those vital issues of vascular biology and contains chapters that specify the medical matters to the elemental scientist in addition to offering clinicians with a systematic grounding in vascular ailments. even though there's nonetheless a lot paintings to be performed to improve knowing of vascular disorder, the data and insights contained during this booklet are an important contribution to the literature, giving scientists and clinicians the chance to profit extra approximately this intriguing box of biomedicine.

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature. 2004;432:173–178. 34. Zimmermann TS, Lee AC, Akinc A, et al. RNAi-mediated gene silencing in non-human primates. Nature. 2006;441:111–114. 35. Frank-Kamenetsky M, Grefhorst A, Anderson NN, et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A. 2008;105:11915–11920. 36. Cartegni L, Chew SL, Krainer AR.

Gene Ther. 2005;12:546–551. 51. Disterer P, Simons JP, Owen JS. Validation of oligonucleotide-mediated gene editing. Gene Ther. 2009;16:824–826. 52. Papaioannou I, Disterer P, Owen JS. Use of internally nuclease-protected single-strand DNA oligonucleotides and silencing the mismatch repair protein, MSH2, enhance replication of corrected cells following gene editing. J Gene Med. 2009;11:267–274. 53. Radecke S, Radecke F, Peter I, Schwarz K. Physical incorporation of a single-stranded oligodeoxynucleotide during targeted repair of a human chromosomal locus.

29 A surgical technique to improve gene delivery efficiency involves treating the heart with permeability agents in vivo. 30 This technique eliminates excess virus, which ultimately reduces peripheral tissue infection. 31,32 Systemic delivery is the ultimate goal of gene therapy as it is, in concept, a simple and noninvasive route of delivery. However, the challenge with this approach is that the body has evolved many highly specific systems to remove foreign particles and pathogens from the bloodstream.

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