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Advances in Pharmacology and Chemotherapy Volume 14 by Silvio Garattini

By Silvio Garattini

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4271, Mansil (Fig. 7). 7. Chemical structure of oxamniquine. CHEMOTHERAPY OF SCHISTOSOMIASIS MANSONI 43 and Richards (1971) described a new series of 2-aminomethyltetrahydroquinoline derivatives displaying strong antischistosomal activity. K. 3883 was selected as one of the most promising schistosomicidal compounds. , 1971b,c; Pellegrino and Katz, 1972). K. 3883 in mice, rats, rabbits, and rhesus monkeys, Kaye and Woolhouse (1972) observed that all these species converted this compound into its 6hydroxymethyl analog, which showed greater schistosomicidal activity in vivo than the parent drug.

1934). More recently, the cellophane thick-smear technique (Kato, 1960) has been widely used with good results. Kato’s technique was evaluated by Martin and Beaver (1968), Chaia et al. (1968), and Katz et al. (1970a). , 1970a). Katz er a f . (1972) reported a simple device for adapting Kato’s quantitative technique to field studies or situations in which an analytical balance is not available. 37-mm thick card with a 6-mm diameter hole in it. After screening the feces through a stainlesssteel sieve (150 pm), the disposable card is placed on a slide and the hole filled with the material.

Rodrigues da Silva (1966a) and Prates and Franco (1966), studying spermatograms or testes biopsies from humans, showed that inhibition of spermatogenesis in man is reversible and not as accentuated as in animals. In vitro tests with Salmonella typhimuriurn histidine auxotrophes showed niridazole to act as a frameshift mutagen. , 1974; Legator et a f . , 1974). , 1968). According to a report from Ciba Laboratories, in about 200,000 cases treated with niridazole, there occurred 6 drug-related deaths (WHO, 1972).

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