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Advances in Cancer Research, Vol. 61 by George F. Vande Woude (ed.), George Klein (ed.)

By George F. Vande Woude (ed.), George Klein (ed.)

Quantity sixty one of "Advances in melanoma study" contains insurance of the subsequent: molecular methods to melanoma remedy, radiation resistance, melanoma prevention learn trials, mammalian gene amplification, retinoblastoma gene functionality, molecular genetic foundation of breast melanoma, and tumour advertising via okadaic acid classification compounds.

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3. , 1991b). Nakamura and colleagues found mutations in the prohibitin gene in 4 of 23 breast carcinomas that showed loss of heterozygosity for chromosome 17q (Sato et al. , 1992); two point mutations resulting in amino acid substitutions; one point mutation possibly interfering with mRNA splicing; and a 2-base deletion resulting in a truncated protein. The prohibitin gene was first MOLECULAR GENETICS IN BREAST CANCER 45 identified from the rat as a gene with the ability to negatively regulate proliferation.

Cytogenetic Studies D. Inactivation of Tumor Suppressor Genes IV. Genetic Predisposition to Breast Cancer V. Concluding Remarks References 1. Introduction T h e view that genetic alterations form the basic steps that change a normal cell into a malignant cell is now widely accepted and an increasing number of genetic alterations are being identified in breast cancer. Most gene alterations found to date have been identified in invasive carcinomas and little is known about genetic changes in carcinoma in situ, the only well-characterized early stage of breast cancer development.

S. J. Pathol. 134, 107-1 13. Kelloff, G. , Malone, W. , Boone, C. , Sigman, C. , and Fay, J. R. Oncol. 17,438-455. Kune, G . , and Watson, L. F. Cancer Res. 48,4399-4404. , et al. Gastroenterology 101,635-639. Lasnitzki, I. Br. J. Cancer 9,434-441. Lipkin, M. Canter Res. 48, 235-245. , Winawer, S. J.. and Newmark, H. L. Cancer Res. 49,248254. , and Newmark, H. L. N . Engl. J. Med. 313, 1381-1384. , Lynch, H. , Blattner, W. , and Fraumeni, J. , Jr. Cancer Lett. 26, 139-144. Lippman, S. , Garewal, H.

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