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Advances in Cancer Research, Vol. 58 by George F. Vande Woude (ed.), George Klein (ed.)

By George F. Vande Woude (ed.), George Klein (ed.)

A part of a serial which offers accomplished reports on advances within the wide box of melanoma learn. This quantity covers all elements of the molecular foundation of human melanoma, discussing such themes as viral interplay with lymphocytes; tumour oncogenesis, rejection and eradication.

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A. 83,5693-5697. , and Katsuki, T. (1978). Int. J . Cancer 21, 426-431. Howe, J. , and Shu, M. D. (1989). Cell 57, 825-834. Hudson, J. , Farrell, P. , and Barrell, B. G. J. Virol. 53, 528-535. Hudson, G. , Bankier, A. , Satchwell, S. , and Barrell, B. G. Vzrology 147,8198. Hurley, E. , and Thorley-Lawson, D. A. J. Exp. Med. 168, 2059-2075. , and Hayward, S. D. J. Virol. 48, 135-148. , Rowe, D. , Nicolas,J. , Farrell, P. , and Perricaudet, M. (1987). J . Virol. 61, 3340-3344. Jones, M. , and Griffin, B.

28 RIK DERYNCK currently know of the existence of a largc variety of growth factors for mammalian cells, most of which can be classified in families of structurally related polypeptides. One of these factors is transforming growth factor-a (TGF-a), which is the subject of this review. We discuss here our current knowledge of the role of TGF-a in the proliferation of normal cells and its potential importance in tumor development. II. , 1972, 1973). , 1991). , 1990). In addition, there are three virally encoded polypeptide factors that also belong to this same family.

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