Adenoviruses: Model and Vectors in Virus-Host Interactions: by M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler,

By M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler, Petra Böhm (eds.)

After 3 volumes on adenoviruses in 1995 the previous years have obvious fast development within the box of adenovirus learn. furthermore, adenoviruses have attracted significant curiosity as vectors in gene move regimens.

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Extra resources for Adenoviruses: Model and Vectors in Virus-Host Interactions: Virion-Structure, Viral Replication and Host-Cell Interactions

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3). We have obtained similar tree topology with partial sequences of the DNA polymerase (BENKO et al. 2002) and the lOOK genes. Following the earlier established hypothesis, the adenoviruses of fishes should represent a fifth genus. The presence of pTP gene in the putative fish adenovirus implies that protein priming exists also in fish adenoviruses. If we accept the abovedescribed evolutionary pathway of adenoviruses, and believe that adeno- 28 H2 H3 H4 H12 H40 H48 S21 S25 P3 C1 E1 B3 M1 FlO F1 F9 0287 87 B8 B4 Rus B5 B6 goat deer poss EDS frog THEV PRD1 M.

Considering that those adenoviruses that are capable of infecting multiple host species seem to be more pathogenic, it is tempting to speculate, that in these cases the virus has not had the time for successful adaptation to the present host. It could also mean that the time of co-existence with the actual host is short: a recent host switch from a very different animal species might have taken place. The E3 region, which did not exist before the development of mastadenoviruses, is certainly an indicator of a high level adaptation to the host.

If we accept that atadenoviruses originate from reptiles, several independent host switches should be presumed. Nowadays, atadenoviruses can be seen in birds, in the brushtail possum and in a number of different ruminant species. We assume that these animals acquired atadenoviruses directly from reptilian hosts, and thus at least two, probably three independent host switches might have happened. The number and variety of serotypes in ruminant species would suggest that ruminants were infected early.

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