2014 Nelson's Pediatric Antimicrobial Therapy by John S. Bradley MD, John D. Nelson MD Emeritus, Dr.

By John S. Bradley MD, John D. Nelson MD Emeritus, Dr. David W Kimberlin MD FAAP, Dr. John A.D. Leake MD MPH, Dr. Paul E Palumbo MD, Dr. Jason Sauberan PharmD, Dr. William J Steinbach

New twentieth Edition!  This bestselling and popular source on pediatric antimicrobial treatment presents quick entry to trustworthy, up to the moment strategies for remedy of all infectious ailments in childrens.  

For each one ailment, the authors supply a observation to aid wellbeing and fitness care services decide on the simplest of all antimicrobial choices.  Drug descriptions disguise all antimicrobial brokers to be had at the present time and comprise entire information regarding dosing regimens. according to transforming into issues approximately overuse of antibiotics, this system comprises directions on while to not prescribe antimicrobials.

Practical, evidence-based concepts from the specialists in antimicrobial treatment:

  • Developed by means of extraordinary editorial board

  • Designed in case you look after childrens and are confronted with judgements each day

  • Includes remedy of parasitic infections and tropical medicine.

  • Updated tests in regards to the energy of the suggestion and the point of proof for remedy innovations for significant infections

  • Anti-infective drug directory, whole with formulations and dosages

  • Antibiotic treatment for overweight children

  • Antimicrobial prophylaxis/prevention of symptomatic infection

  • Maximal grownup dosages and better dosages of a few antimicrobials standard in children

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B Desired serum concentrations: 20–30 mg/L (peak), <5 mg/L (trough). c Desired serum concentrations: 5–10 mg/L (peak), <2 mg/L (trough). a C. AMINOGLYCOSIDES Empiric Dosage (mg/kg/dose) by Gestational and Postnatal Age 2014 Nelson’s Pediatric Antimicrobial Therapy — 35 5 3/13/14 2:54 PM 36 — Chapter 5. Antimicrobial Therapy for Newborns E. Use of Antimicrobials During Pregnancy or Breastfeeding Antimicrobial Therapy for Newborns The use of antimicrobials during pregnancy should be balanced by the risk of fetal toxicity, including anatomical anomalies.

48 Monitor for neutropenia during suppressive therapy. For recurrent cutaneous disease, oral acyclovir until lesions crusted (assuming CNS disease at the time of cutaneous recurrence). 15% ganciclovir ophthalmic gel) (AII). Obtain CSF PCR for HSV to assess for CNS infection. indb 22 Group A streptococcus usually causes “wet cord” without pus and with minimal erythema; single dose of benazthine penicillin IM adequate. Consultation with pediatric ID specialist is recommended for necrotizing fasciitis (AII).

If CSF positive, repeat spinal tap with CSF VDRL at 6 mo, and if abnormal, re-treat. 5 Syphilis, congenital (<1 mo of age)88 Condition Comments Antimicrobial Therapy for Newborns A. RECOMMENDED THERAPY FOR SELECTED NEWBORN CONDITIONS (cont) 28 — Chapter 5. indb 29 Antimicrobial Therapy for Newborns Metronidazole IV/PO (alternative: penicillin G IV) for 10–14 days (AIII) Human TIG 3,000–6,000 U IM for 1 dose (AIII) Wound cleaning and debridement vital; IVIG (200–400 mg/kg) is an alternative if TIG not available; equine tetanus antitoxin not available in the United States but is alternative to TIG.

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